Rapid magnetic resonance quantification on the brain: Optimization for clinical usage
Open Access
- 29 July 2008
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 60 (2), 320-329
- https://doi.org/10.1002/mrm.21635
Abstract
A method is presented for rapid simultaneous quantification of the longitudinal T1 relaxation, the transverse T2 relaxation, the proton density (PD), and the amplitude of the local radio frequency B1 field. All four parameters are measured in one single scan by means of a multislice, multiecho, and multidelay acquisition. It is based on a previously reported method, which was substantially improved for routine clinical usage. The improvements comprise of the use of a multislice spin‐echo technique, a background phase correction, and a spin system simulation to compensate for the slice‐selective RF pulse profile effects. The aim of the optimization was to achieve the optimal result for the quantification of magnetic resonance parameters within a clinically acceptable time. One benchmark was high‐resolution coverage of the brain within 5 min. In this scan time the measured intersubject standard deviation (SD) in a group of volunteers was 2% to 8%, depending on the tissue (voxel size = 0.8 × 0.8 × 5 mm). As an example, the method was applied to a patient with multiple sclerosis in whom the diseased tissue could clearly be distinguished from healthy reference values. Additionally it was shown that, using the approach of synthetic MRI, both accurate conventional contrast images as well as quantification maps can be generated based on the same scan. Magn Reson Med 60:320–329, 2008.Keywords
This publication has 22 references indexed in Scilit:
- High‐resolution T1 mapping of the brain at 3T with driven equilibrium single pulse observation of T1 with high‐speed incorporation of RF field inhomogeneities (DESPOT1‐HIFI)Journal of Magnetic Resonance Imaging, 2007
- Novel method for rapid, simultaneous T1, T*2, and proton density quantificationMagnetic Resonance in Medicine, 2007
- A new method for fast quantitative mapping of absolute water content in vivoNeuroImage, 2006
- Full‐brain T1 mapping through inversion recovery fast spin echo imaging with time‐efficient slice orderingMagnetic Resonance in Medicine, 2005
- Fast high‐resolution T1 mapping of the human brainMagnetic Resonance in Medicine, 2005
- High‐resolution T1 and T2 mapping of the brain in a clinically acceptable time with DESPOT1 and DESPOT2Magnetic Resonance in Medicine, 2004
- Quantitative MRI of the BrainPublished by Wiley ,2003
- Rapid T1 mapping using multislice echo planar imagingMagnetic Resonance in Medicine, 2001
- In vivo measurement of T2 distributions and water contents in normal human brainMagnetic Resonance in Medicine, 1997
- High‐speed multislice T1 mapping using inversion‐recovery echo‐planar imagingMagnetic Resonance in Medicine, 1990