Impact of repeated large scale ivermectin treatments on the transmission of Loa loa.
- 1 July 1998
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 92 (4), 454-458
- https://doi.org/10.1016/s0035-9203(98)91091-4
Abstract
We have studied the impact of large-scale treatment with ivermectin on the transmission of loiasis in a forest village in south Cameroon where loiasis was highly endemic, with a prevalence of 30%. After one year of parasitological and entomological surveillance without treatment, all consenting residents aged >5 years received ivermectin 200 μg/kg every 3 months. For ethical reasons, treatment was interrupted after 2 years, but parasitological and entomological surveillance continued for 18 months after the end of treatment. The prevalence of loiasis was reduced to Chrysops dimidiata (representing about 90% of the fly population) and C. silacea.The infection rate (all stages) in Chrysops decreased by 75% and the infective rate (percentage of Chrysops harbouring third-stage larvae of Loa loa in the head) decreased by 85% in C. dimidiata and became zero in C. silacea. After the end of treatment, the infection and infective rates increased gradually. Large-scale treatment seemed an efficient method for the control of L. loa transmission provided high drug coverage was achieved. Nevertheless, because of the high risk of adverse effects when using the current microfilaricidal drugs, such a strategy remains unacceptable.Keywords
This publication has 14 references indexed in Scilit:
- Severe adverse reaction risks during mass treatment with ivermectin in loiasis-endemic areasParasitology Today, 1996
- Ivermectin treatment of loiasisTransactions of the Royal Society of Tropical Medicine and Hygiene, 1992
- Chrysops silacea and C. dimidiata: fly densities and infection rates with Loa loa in the Chaillu mountains, Congo RepublicTransactions of the Royal Society of Tropical Medicine and Hygiene, 1990
- Loa loa — a neglected filariaParasitology Today, 1988
- Studies on the Control of the Vectors of Loiasis in West AfricaPathogens and Global Health, 1963
- The Bionomics ofChrysops SilaceaAusten, 1907Pathogens and Global Health, 1963
- A Trial of Banocide as a Means of Controlling the Transmission of Loiasis on a Rubber Estate in NigeriaPathogens and Global Health, 1961
- Studies on the Biting Habits ofChrysopsPathogens and Global Health, 1960
- Studies on the Biting Habits ofChrysopsPathogens and Global Health, 1955
- The Biting Habits ofChrysops Silaceain the Forest at Kumba, British CameroonsPathogens and Global Health, 1951