Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art
Open Access
- 7 November 2013
- journal article
- review article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2013, 1-11
- https://doi.org/10.1155/2013/416391
Abstract
Adipose tissue represents a hot topic in regenerative medicine because of the tissue source abundance, the relatively easy retrieval, and the inherent biological properties of mesenchymal stem cells residing in its stroma. Adipose-derived mesenchymal stem cells (ASCs) are indeed multipotent somatic stem cells exhibiting growth kinetics and plasticity, proved to induce efficient tissue regeneration in several biomedical applications. A defined consensus for their isolation, classification, and characterization has been very recently achieved. In particular, bone tissue reconstruction and regeneration based on ASCs has emerged as a promising approach to restore structure and function of bone compromised by injury or disease. ASCs have been used in combination with osteoinductive biomaterial and/or osteogenic molecules, in either static or dynamic culture systems, to improve bone regeneration in several animal models. To date, few clinical trials on ASC-based bone reconstruction have been concluded and proved effective. The aim of this review is to dissect the state of the art on ASC use in bone regenerative applications in the attempt to provide a comprehensive coverage of the topics, from the basic laboratory to recent clinical applications.Keywords
This publication has 141 references indexed in Scilit:
- Effect of Anatomical Origin and Cell Passage Number on the Stemness and Osteogenic Differentiation Potential of Canine Adipose-Derived Stem CellsStem Cell Reviews and Reports, 2012
- Gene-Modified Adult Stem Cells Regenerate Vertebral Bone Defect in a Rat ModelMolecular Pharmaceutics, 2011
- Locally Applied Vascular Endothelial Growth Factor A Increases the Osteogenic Healing Capacity of Human Adipose-Derived Stem Cells by Promoting Osteogenic and Endothelial DifferentiationThe International Journal of Cell Cloning, 2010
- A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese miceInternational Journal of Obesity, 2010
- Enhanced bone formation in large segmental radial defects by combining adipose-derived stem cells expressing bone morphogenetic protein 2 with nHA/RHLC/PLA scaffoldInternational Orthopaedics, 2010
- Stromal vascular progenitors in adult human adipose tissueCytometry Part A, 2009
- A tissue engineering approach to bone repair in large animal models and in clinical practiceBiomaterials, 2007
- Relationships between fat and boneOsteoporosis International, 2007
- Bone induction by BMP‐2 transduced stem cells derived from human fatJournal of Orthopaedic Research, 2003
- Surface protein characterization of human adipose tissue‐derived stromal cellsJournal of Cellular Physiology, 2001