Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer
- 31 March 2018
- journal article
- review article
- Published by Informa UK Limited in Future Medicinal Chemistry
- Vol. 10 (8), 961-976
- https://doi.org/10.4155/fmc-2017-0198
Abstract
Natural products have been gaining recognition and are becoming a significant part of research in the area of drug development and discovery. Phytochemicals derived from these sources have been comprehensively studied and have displayed a wide range of activities against many fatal diseases including cancer. One such product that has gained recognition from its pharmacological properties and nontoxic nature is embelin, obtained from Embelia ribes. Amid all the vivid pharmacological activities, embelin has gained its prominence in the area of cancer research. Embelin binds to the BIR3 domain of XIAP, preventing the association of XIAP and caspase-9 resulting in the suppression of cell growth, proliferation and migration of various types of cancer cells. Furthermore, embelin modulates anti-apoptotic pathways by suppressing the activity of NF-kappa B, PI3-kinase/AKT, JAK/STAT pathway - among others. The present review summarizes the various reported effects of embelin on different types of cancer cells and highlights the cellular mechanisms of action.Keywords
This publication has 108 references indexed in Scilit:
- Anti-Inflammatory Benefits of Antibiotic-Induced Neutrophil Apoptosis: Tulathromycin Induces Caspase-3-Dependent Neutrophil Programmed Cell Death and Inhibits NF-κB Signaling and CXCL8 TranscriptionAntimicrobial Agents and Chemotherapy, 2011
- Modern Natural Products Drug Discovery and Its Relevance to Biodiversity ConservationJournal of Natural Products, 2010
- Embelin Suppresses Osteoclastogenesis Induced by Receptor Activator of NF-κB Ligand and Tumor CellsIn vitrothrough Inhibition of the NF-κB Cell Signaling PathwayMolecular Cancer Research, 2010
- XIAP Gene Expression Protects β-Cells and Human Islets from Apoptotic Cell DeathMolecular Pharmaceutics, 2010
- X-Linked Inhibitor of Apoptosis Protein Inhibits Apoptosis in Inflammatory Breast Cancer Cells with Acquired Resistance to an ErbB1/2 Tyrosine Kinase InhibitorMolecular Cancer Therapeutics, 2010
- Macrophage Diversity Enhances Tumor Progression and MetastasisCell, 2010
- Immunity, Inflammation, and CancerCell, 2010
- IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated CancerCancer Cell, 2009
- JNK signaling in apoptosisOncogene, 2008
- Tumour-educated macrophages promote tumour progression and metastasisNature Reviews Cancer, 2004