Alcohol consumption and risk of pre‐diabetes and type 2 diabetes development in a Swedish population
- 12 March 2012
- journal article
- research article
- Published by Wiley in Diabetic Medicine
- Vol. 29 (4), 441-452
- https://doi.org/10.1111/j.1464-5491.2011.03450.x
Abstract
Aims Alcohol is a potential risk factor of Type 2 diabetes. However, more detailed information on effects of alcohol types and early phases of Type 2 diabetes development seems warranted. The aim of this study was to investigate the influence of alcohol consumption and specific alcoholic beverages on the risk of developing pre-diabetes and Type 2 diabetes in middle-aged Swedish men and women. Methods Subjects, who at baseline had normal glucose tolerance (2070 men and 3058 women) or pre-diabetes (70 men and 41 women), aged 3556 years, were evaluated in this cohort study. Logistic regression was performed to estimate the risk [odds ratio (OR) and 95% confidence interval (CI)] to develop pre-diabetes and Type 2 diabetes at 810 years follow-up, in relation to self-reported alcohol intake at baseline. Adjustment was performed for several risk factors. Results Total alcohol consumption and binge drinking increased the risk of pre-diabetes and Type 2 diabetes in men (OR 1.42, 95% CI 1.002.03 and OR 1.67, 95% CI 1.112.50, respectively), while low consumption decreased diabetes risk in women (OR 0.41, 95% CI 0.220.79). Men showed higher risk of pre-diabetes with high beer consumption (OR 1.84, 95% CI 1.133.01) and of Type 2 diabetes with high consumption of spirits (OR 2.03, 95% CI 1.273.24). Women showed a reduced risk of pre-diabetes with high wine intake (OR 0.66, 95% CI 0.430.99) and of Type 2 diabetes with medium intake of both wine and spirits (OR 0.46, 95% CI 0.240.88 and OR 0.55, 95% CI 0.310.97, respectively), whereas high consumption of spirits increased the pre-diabetes risk(OR 2.41, 95% CI 1.473.96). Conclusion High alcohol consumption increases the risk of abnormal glucose regulation in men. In women the associations are more complex: decreased risk with low or medium intake and increased risk with high alcohol intake.Keywords
This publication has 25 references indexed in Scilit:
- Socio-demographic, lifestyle and health characteristics among snus users and dual tobacco users in Stockholm County, SwedenBMC Public Health, 2010
- Alcohol as a Risk Factor for Type 2 DiabetesDiabetes Care, 2009
- Psychological distress and risk of pre‐diabetes and Type 2 diabetes in a prospective study of Swedish middle‐aged men and womenDiabetic Medicine, 2008
- Sweden—is alcohol becoming an ordinary commodity?Addiction, 2006
- Alcohol Consumption and the Incidence of Type 2 DiabetesDiabetes Care, 2003
- The association between alcohol consumption and all-cause mortality in a cohort of male employees in the German construction industry.International Journal of Epidemiology, 1997
- Light-to-Moderate Alcohol Intake Is Associated With Enhanced Insulin SensitivityDiabetes Care, 1994
- Genetic and environmental determinants of non‐insulin‐dependent diabetes mellitus (NIDDM)Diabetes/Metabolism Research and Reviews, 1992
- Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance.JCI Insight, 1988
- Effects of ethanol ingestion on glucose tolerance and insulin secretion in normal and diabetic subjectsMetabolism, 1975