Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans
Open Access
- 18 November 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in AGE
- Vol. 35 (1), 251-259
- https://doi.org/10.1007/s11357-011-9341-2
Abstract
Relationship between thymic function and elderly survival has been suspected, despite the fact that formal proof is elusive due to technical limitations of thymic function-related markers. The newly described sj/β-TREC ratio allows now, by overcoming these limitations, an accurate measurement of thymic output in elderly humans. Thus, the aim of this study was to determine the impact of thymic function and inflammatory markers on healthy elderly human survival. Healthy volunteers (n = 151), aged over 65, were asked to participate (CARRERITAS cohort). Subjects were excluded if diagnosed of dementia or, during the last 6 months, had clinical data of infection, hospital admission, antitumor therapy, or any treatment that could influence the immune status. Thymic function (sj/β-TREC ratio), CD4:CD8 T cell ratio, C-reactive protein, interleukin-6, and neutrophilia were determined from basal samples. All basal variables and age were associated with 2-year all-cause mortality. Multivariate analysis showed that only thymic function and C-reactive protein were independently associated with time to death. In conclusion, we show, for the first time, the direct role of thymic function in human survival. C-reactive protein raise is also a marker of mortality in the healthy elderly, in a thymic-independent way.Keywords
This publication has 37 references indexed in Scilit:
- Immunosenescence: Implications for vaccination programmes in adultsMaturitas, 2011
- Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United StatesPLOS ONE, 2011
- Age-related deregulation of naive T cell homeostasis in elderly humansAGE, 2010
- Systemic inflammation (Interleukin 6) predicts all-cause mortality in men: results from a 9-year follow-up of the MEMO StudyAGE, 2010
- Aging, imbalanced inflammation and viral infectionVirulence, 2010
- Thymopoiesis in elderly human is associated with systemic inflammatory statusAGE, 2009
- Biology of Immune Responses to Vaccines in Elderly PersonsClinical Infectious Diseases, 2008
- T cell subset-specific susceptibility to agingClinical Immunology, 2008
- Aging and the dendritic cell system: Implications for cancerCritical Reviews in Oncology/Hematology, 2007
- Immunosenescence: emerging challenges for an ageing populationImmunology, 2007