Plasma antioxidant potential in severe sepsis
- 1 July 1996
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Critical Care Medicine
- Vol. 24 (7), 1179-1183
- https://doi.org/10.1097/00003246-199607000-00019
Abstract
To determine the plasma antioxidant potential of patients in the intensive care unit (ICU) with severe sepsis and secondary organ dysfunction and relate these findings to outcome. A prospective, cohort study. A nine-bed ICU in a university teaching hospital. Fifteen consecutive patients, who were within 16 hrs of development of severe sepsis and secondary organ dysfunction. Plasma samples were obtained within 16 hrs of the onset of secondary organ dysfunction and subsequently on days 2, 3, 4, 6, 8, 10, and 15 until patients either left the ICU or died. Plasma antioxidant potential was determined by an ultraviolet spectrophotometric technique. The mean initial plasma antioxidant potential was lower than our range for healthy volunteers (p < .05). Survivors had an initial plasma antioxidant potential that was greater than nonsurvivors (p < .01), and serial subset analysis demonstrated that survivors, despite having a low initial plasma antioxidant potential rapidly attained normal or supranormal values. While plasma antioxidant potential also increased in nonsurvivors over time, values in this subset never reached the normal range and remained below values in survivors at all time points studied (p < .05). Plasma antioxidant potential is initially decreased in patients with sepsis who develop organ dysfunction, and it increases over time. While we have no clear evidence to prove that this reduction has a causal relationship, failure to achieve a normal plasma antioxidant potential is strongly associated with an unfavorable outcome.Keywords
This publication has 24 references indexed in Scilit:
- Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunctionCritical Care Medicine, 1995
- Agonist-Induced Peroxynitrite Production from Endothelial CellsArchives of Biochemistry and Biophysics, 1994
- Very large-scale, randomized, clinical trials in sepsis and septic shockCritical Care Medicine, 1994
- A Novel Method for Measuring Antioxidant Capacity and its Application to Monitoring the Antioxidant Status in Premature NeonatesClinical Science, 1993
- Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats.JCI Insight, 1991
- Plasma lipid peroxides and antioxidants in human septic shockIntensive Care Medicine, 1991
- Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.Proceedings of the National Academy of Sciences of the United States of America, 1990
- Antioxidant defenses and lipid peroxidation in human blood plasma.Proceedings of the National Academy of Sciences of the United States of America, 1988
- APACHE IICritical Care Medicine, 1985
- Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenaseArchives of Biochemistry and Biophysics, 1976