Antibacterial and Antiandrogen Flavonoids from Sophora flavescens
- 25 November 1999
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (12), 1595-1599
- https://doi.org/10.1021/np990051d
Abstract
Sixteen flavanones, three flavanonols, and four pterocarpans were isolated from the MeOH extract of the roots of Sophora flavescens. Twelve of these were new compounds, including eight prenylflavanones (1−8), one prenylflavanonol (9), and three novel pterocarpane derivatives (10−12). Their structures were elucidated using NMR and mass spectral methods. Some of these compounds have irregular C10 prenyl moieties at C-8 of the flavanone skeleton. These compounds exhibited significant antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, S. epidermidis, and Propionibacterium acnes. They also exhibited antiandrogen activities.Keywords
This publication has 4 references indexed in Scilit:
- Detoxification of the phytoalexins maackiain and medicarpin by fungal pathogens of alfalfaPhytochemistry, 1996
- Studies on the Constituents of Sophora Species. V. Constituents of the Root of Sophora angustifolia SIEB. et ZUCC. (2)CHEMICAL & PHARMACEUTICAL BULLETIN, 1971
- Circular dichroism, optical rotatory dispersion and absolute configuration of flavanones, 3-hydroxyflavanones and their glycosidesTetrahedron, 1970
- Lupinen‐Alkaloide, XI. Die Alkaloide aus Sophora flavescensEuropean Journal of Inorganic Chemistry, 1958