EXTRASKELETAL MYXOID CHONDROSARCOMA: A Clinicopathologic and Electron Microscopic Study

Abstract

Fourteen cases of extraskeletal myxoid chondrosarcoma are presented from 603 cases of soft tissue sarcomas. The ages of the patients at initial biopsy ranged from 16-69 yr. The tumors mainly arose in the lower extremities including buttocks (10 cases). They consisted histologically in cords and strands of small acidophilic cells with occasional vacuolated cells in an abundant myxoid matrix composed of chondroitin sulfate. EM in 4 revealed a continuum of cell differentiation of the tumor cells from chondroblastic cell to undifferentiated mesenchymal cell. Morphological studies indicated that the extraskeletal myxoid chondrosarcoma included so-called chordoid sarcoma as a variant.