Fusariosis
- 23 September 2015
- journal article
- review article
- Published by Georg Thieme Verlag KG in Seminars in Respiratory and Critical Care Medicine
- Vol. 36 (05), 706-714
- https://doi.org/10.1055/s-0035-1562897
Abstract
Fusarium species are frequent agents of onychomycosis and fungal keratitis, and occasional agents of invasive disease. The clinical spectrum of fusariosis in the lungs includes allergic disease (allergic bronchopulmonary fusariosis), hypersensitivity pneumonitis, colonization of a preexisting cavity, and pneumonia. Fusarial pneumonia occurs almost exclusively in severely immunocompromised patients, especially acute leukemia patients and recipients of allogeneic cell transplantation. In such patients, invasive fusariosis is usually disseminated, and pneumonia occurs in almost 50% of cases. The radiologic picture is similar to invasive aspergillosis, with alveolar infiltrates, nodules with or without halo sign, ground-glass infiltrates, and pleural effusions. Different from aspergillosis is the frequent occurrence of disseminated nodular and papular skin lesions and positive blood cultures. The drug of choice for the treatment of invasive fusariosis is either voriconazole or liposomal amphotericin B. The outcome is usually poor, and largely dependent on the recovery of the immune status of the host, particularly neutropenia.Keywords
This publication has 108 references indexed in Scilit:
- Fatal DisseminatedFusariumInfection in a Human Immunodeficiency Virus Positive PatientCase Reports in Infectious Diseases, 2013
- Cross-Reactivity of Fusarium spp. in the Aspergillus Galactomannan Enzyme-Linked Immunosorbent AssayJournal of Clinical Microbiology, 2012
- Disseminated Fusariosis Occurring in Two Patients Despite Posaconazole ProphylaxisJournal of Clinical Microbiology, 2011
- Internet-Accessible DNA Sequence Database for Identifying Fusaria from Human and Animal InfectionsJournal of Clinical Microbiology, 2010
- Less-FrequentFusariumSpecies of Clinical Interest: Correlation between Morphological and Molecular Identification and Antifungal SusceptibilityJournal of Clinical Microbiology, 2009
- Species-Specific Identification of a Wide Range of Clinically Relevant Fungal Pathogens by Use of Luminex xMAP TechnologyJournal of Clinical Microbiology, 2009
- Molecular Phylogenetic Diversity, Multilocus Haplotype Nomenclature, and In Vitro Antifungal Resistance within theFusarium solaniSpecies ComplexJournal of Clinical Microbiology, 2008
- Species Distribution and In Vitro Antifungal Susceptibility Patterns of 75 Clinical Isolates of Fusarium spp. from Northern ItalyAntimicrobial Agents and Chemotherapy, 2008
- Fusarium Infections in Immunocompromised PatientsClinical Microbiology Reviews, 2007
- Diagnosis of fusariosis in urine cytologyJournal of Clinical Pathology, 2006