Early Visual and Morphologic Changes After Half-Fluence Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Abstract

To evaluate the early functional and morphologic changes in patients with chronic central serous chorioretinopathy (CSC) after half-fluence photodynamic therapy (PDT) and to compare with fellow eyes. This prospective study included 32 symptomatic and 28 fellow eyes of 32 patients with chronic CSC. Indocyanine green angiography-guided half-fluence PDT (25 J/cm(2)) was performed. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), and subfoveal choroidal thickness (SFCT) were evaluated at baseline and at days 1, 3, 7, 30, and 60 after PDT. The mean age was 48.1±7.9 years. Baseline BCVA [logarithm of the minimum angle of resolution (logMAR)] improved from 0.56±0.23 to 0.54±0.24, 0.45±0.25, 0.38±0.23, 0.36±0.23, and 0.35±0.21 at days 1, 3, 7, 30, and 60. (P=0.91, P=0.004, P=0.002, P=0.001, and P<0.001, respectively). Baseline CFT decreased from 315±131 to 312±136, 305±136, 235±106, 174±44, and 165±36 μm at days 1, 3, 7, 30, and 60 (P=0.41, P=0.33, P=0.004, P<0.001, and P<0.001, respectively). Baseline SFCT in the symptomatic eyes was significantly greater compared with the fellow eyes (P=0.002) and changed from 517±98 to 546±109, 528±110, 495±119, 462±124, and 457±123 μm at days 1, 3, 7, 30, and 60 (P=0.02, P=0.42, P=0.07, P=0.004, P=0.003, respectively). The SFCT in the symptomatic eyes was greater in the fellow eyes at baseline. Functional and morphological chorioretinal changes started in very early period of treatment. Half-fluence PDT for chronic CSC resulted in thinner CFT and SFCT, and also showed a significant improvement in visual acuity.