Inositol 1,4,5‐trisphosphate activates two types of Ca2+‐permeable channels in human carcinoma cells
- 17 December 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 277 (1-2), 233-234
- https://doi.org/10.1016/0014-5793(90)80853-b
Abstract
Ca2+-permeable channels in human carcinoma A431 cells were studied using the patch clamp technique. We have found two types of Ca2+-penneable channels which are activated by inositol 1,4,5-trisphosphate (IP3) applied to the intracellular side of the plasma membrane. Unitary conductances of these channels are 3.7 and 13 pS (105 mM Ca2+ in recording pipette, 30–33°C). From the extracellular side of the membrane the channels are activated by EGF. It is assumed that extracellular agonists open both channel types by stimulating the release of IP3 from the membrane.Keywords
This publication has 11 references indexed in Scilit:
- Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.Cell Regulation, 1989
- Transmembrane signalling at the epidermal growth factor receptorTrends in Pharmacological Sciences, 1989
- Inositol phosphates and cell signallingNature, 1989
- Epidermal growth factor activates calcium-permeable channels in A 431 cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
- Inositol 1,4,5-trisphosphate activates a channel from smooth muscle sarcoplasmic reticulumNature, 1988
- Calcium-mobilizing receptorsTrends in Pharmacological Sciences, 1987
- Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channelsNature, 1987
- G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALSAnnual Review of Biochemistry, 1987
- Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytesNature, 1987
- Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesPflügers Archiv - European Journal of Physiology, 1981