DO LONG‐STANDING NODULAR GOITRES RESULT IN MALIGNANCIES?
- 1 March 1994
- journal article
- Published by Wiley in Anz Journal of Surgery
- Vol. 64 (3), 180-182
- https://doi.org/10.1111/j.1445-2197.1994.tb02173.x
Abstract
The records of 506 patients with histologically proven nodular goitre treated by thyroidectomy between January 1966 and July 1988 were reviewed. There were 21 patients with thyroid carcinoma in nodular goitre giving a proportion of 4.1%. There was an almost equal ratio of papillary to follicular carcinomas in the patients with malignancy occurring in a multinodular goitre (11 papillary to 9 follicular). One had an anaplastic lesion. These patients had swelling for a longer period, 9.11 years, as compared with an average of 5.48 years for those with only nodular goitre (P = < 0.01) using the Student's t-test. The male to female ratio in those with multinodular goitre alone was 1:10.8 while in those with carcinoma in multinodular goitre was 1:3.2. Comparing these two groups, the odds ratio of malignancy among males was 2.82 (95% confidence limits of the odds ratio being 1.4-5.5). This indicates that males with multinodular goitre had a significantly higher chance of developing a malignancy, Chi-squared value 5.74 (P < 0.05).Keywords
This publication has 8 references indexed in Scilit:
- Carcinoma in multinodular goitreBritish Journal of Surgery, 1992
- The Problem of the Nodular GoiterMedical Clinics of North America, 1991
- Thyroid CancerMedical Clinics of North America, 1991
- Occult thyroid carcinoma at autopsy in Malmö, SwedenCancer, 1981
- Incidence of thyroid carcinoma in Graves' diseaseCancer, 1970
- THE PROBLEM OF MALIGNANCY IN NODULAR GOITER-RECAPITULATION AND A CHALLENGEJournal of the American Medical Association, 1959
- NODULAR GOITER AND MALIGNANT LESIONS OF THE THYROID GLAND*Journal of Clinical Endocrinology & Metabolism, 1951
- POTENTIAL DANGERS OF NONTOXIC NODULAR GOITERJournal of the American Medical Association, 1945