Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang
- 4 February 2013
- journal article
- research article
- Published by Taylor & Francis Ltd in Pharmaceutical Biology
- Vol. 51 (5), 629-634
- https://doi.org/10.3109/13880209.2012.761243
Abstract
Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug. Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the anti-inflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p < 0.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant anti-inflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.Keywords
This publication has 26 references indexed in Scilit:
- Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South AfricaJournal of Ethnopharmacology, 2011
- Antibiotic resistance and its cost: is it possible to reverse resistance?Nature Reviews Microbiology, 2010
- Bioactivity guided evaluation of anti-inflammatory and antinociceptive activities of Arceuthobium oxycedri (D.C.) M. Bieb.Journal of Ethnopharmacology, 2010
- Antibacterial potentials of aqueous extract of Enantia chlorantha stem barkAFRICAN JOURNAL OF BIOTECHNOLOGY, 2007
- Anti-infective antibodies: finding the path forwardNature Biotechnology, 2006
- The business of developing antibacterialsNature Biotechnology, 2006
- Antibacterial and antioxidant activities in Sideritis italica (Miller) Greuter et Burdet essential oilsJournal of Ethnopharmacology, 2006
- Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum LinnéJournal of Ethnopharmacology, 2005
- Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extractJournal of Ethnopharmacology, 2002
- A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: An application of Saiboku-To in bronchial asthmaAnalytical Biochemistry, 1992