Glial and neuronal antibodies in patients with idiopathic intracranial hypertension
- 21 July 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neurological Sciences
- Vol. 38 (10), 1817-1822
- https://doi.org/10.1007/s10072-017-3066-7
Abstract
Headache and visual disturbances are the main presenting symptoms of idiopathic intracranial hypertension (IIH) characterized by increased intracranial pressure (ICP) with an unknown cause. We aimed to investigate the antibodies against optic neuritis-associated glial antigens, aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) and uncharacterized neuronal membrane antigens in IIH patients. Consecutive patients diagnosed according to Friedman revised diagnostic criteria and control subjects were included after their consent. All serum samples were analyzed for antibodies against AQP4 and MOG using cell-based immunofluorescent assays and for uncharacterized neuronal membrane antigens by indirect immunocytochemistry utilizing live neurons. Sera of 34 patients with IIH and 40 control subjects were investigated but none of the patients showed AQP4 and MOG antibodies. However, serum IgG of five IIH patients showed reactivity against membrane antigens of rat hippocampal and cortical neurons. Interestingly, three out of these five patients had nonspecific white matter lesions on MRI, whereas only four of all other patients had these lesions (p = 0.048). AQP4 and MOG antibodies do not seem to have a role in the pathophysiology of IIH. However, association of immunocytochemistry findings with the presence of white matter lesions may suggest that immunological factors contribute to the pathogenesis of IIH in at least some of the patients.Keywords
Funding Information
- Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi (21774)
This publication has 30 references indexed in Scilit:
- Differences in distribution and regulation of astrocytic aquaporin‐4 in human and rat hydrocephalic brainNeuropathology and Applied Neurobiology, 2013
- Aquaporin-4 antibodies and idiopathic intracranial hypertension: the jury is in and the channels are out.Cephalalgia, 2012
- Aquaporin-4 antibodies are not present in patients with idiopathic intracranial hypertensionCephalalgia, 2012
- The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical NeuronsPLOS ONE, 2011
- Expression of Aquaporin 1 and 4 in a Congenital Hydrocephalus Rat ModelNeurosurgery, 2011
- N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexesBrain, 2010
- Exploring the pathogenesis of IIH: An inflammatory perspectiveJournal of Neuroimmunology, 2008
- Mammalian aquaporins: diverse physiological roles and potential clinical significanceExpert Reviews in Molecular Medicine, 2008
- Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edemaThe FASEB Journal, 2004
- The molecular basis of water transport in the brainNature Reviews Neuroscience, 2003