Progesterone as a neurosteroid: Actions within the nervous system
- 1 April 1996
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Neurobiology
- Vol. 16 (2), 143-154
- https://doi.org/10.1007/bf02088173
Abstract
1. Some progesterone is synthesized within both the central and the peripheral nervous systems, where it regulates neurotransmission and important glial functions, such as the formation of myelin. Progesterone can thus be designated a “neurosteroid.” 2. Steroids act not only on the brain, but also on peripheral nerves, which offer many advantages to study the biological significance of locally produced neurosteroids: their remarkable plasticity and regenerative capacity and their relatively simple structure. 3. By using the regenerating mouse sciatic nerve as a model, we have shown that progesterone synthesized by rat Schwann cells promotes the formation of new myelin sheaths. Progesterone also increases the number of myelinated axons when added at a low concentration to cocultures of Schwann cells and sensory neurons. 4. These findings show a function on myelination for locally produced progesterone and suggest a new pharmacological approach of myelin repair.Keywords
This publication has 52 references indexed in Scilit:
- Myelination and myelin sheath remodelling in normal and pathological PNS nerve fibresProgress in Neurobiology, 1994
- The genetics of myelinCurrent Opinion in Neurobiology, 1993
- Evidence for a recessive PMP22 point mutation in Charcot–Marie–Tooth disease type 1ANature Genetics, 1993
- Allosteric modulations of the nicotinic acetylcholine receptorTrends in Neurosciences, 1993
- Stimulation of rat Schwann cell proliferation by estradiol: synergism between the estrogen and cAMPDevelopmental Brain Research, 1993
- Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroidEuropean Journal of Pharmacology: Molecular Pharmacology, 1991
- Neurosteroids: a new function in the brainBiology of the Cell, 1991
- Behavioral Effects of Progesterone Associated with Rapid Modulation of Oxytocin ReceptorsScience, 1990
- Peripheral Nerve RegenerationAnnual Review of Neuroscience, 1990
- Hormonal Modulation of Schwann Cell Tumors.Annals of the New York Academy of Sciences, 1986