Chromosome aberrations in solid tumors
- 30 July 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 34 (4), 369-376
- https://doi.org/10.1038/ng1215
Abstract
Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.Keywords
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