Synthesis, Characterization, and Three-Dimensional Structure Generation of Zinc Oxide-Based Nanomedicine for Biomedical Applications
Open Access
- 4 November 2019
- journal article
- review article
- Published by MDPI AG in Pharmaceutics
- Vol. 11 (11), 575
- https://doi.org/10.3390/pharmaceutics11110575
Abstract
Zinc oxide (ZnO) nanoparticles have been studied as metal-based drugs that may be used for biomedical applications due to the fact of their biocompatibility. Their physicochemical properties, which depend on synthesis techniques involving physical, chemical, biological, and microfluidic reactor methods affect biological activity in vitro and in vivo. Advanced tool-based physicochemical characterization is required to identify the biological and toxicological effects of ZnO nanoparticles. These nanoparticles have variable morphologies and can be molded into three-dimensional structures to enhance their performance. Zinc oxide nanoparticles have shown therapeutic activity against cancer, diabetes, microbial infection, and inflammation. They have also shown the potential to aid in wound healing and can be used for imaging tools and sensors. In this review, we discuss the synthesis techniques, physicochemical characteristics, evaluation tools, techniques used to generate three-dimensional structures, and the various biomedical applications of ZnO nanoparticles.Keywords
This publication has 191 references indexed in Scilit:
- Hydrothermal synthesis of zinc oxide nanoparticles using rice as soft biotemplateChemistry Central Journal, 2013
- Tunable ZnO quantum dots for bioimaging: synthesis and photoluminescenceMaterials Technology, 2013
- Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitisClinical, Cosmetic and Investigational Dermatology, 2013
- Face-selective electrostatic control of hydrothermal zinc oxide nanowire synthesisNature Materials, 2011
- Water Molecule-Induced Stiffening in ZnO NanobeltsNano Letters, 2011
- Tuning the band gap of ZnO nanoparticles by ultrasonic irradiationInorganic Materials, 2010
- ZnO-Based Amperometric Enzyme BiosensorsSensors, 2010
- Biological and Biomimetic MaterialsAdvanced Materials, 2009
- Biomimetic materials research: what can we really learn from nature's structural materials?Journal of The Royal Society Interface, 2007
- Controlled Precipitation of Zinc Oxide Particles at Room TemperatureChemistry of Materials, 2003