A New Approach to Dissolution Testing by UV Imaging and Finite Element Simulations
- 11 January 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 30 (5), 1328-1337
- https://doi.org/10.1007/s11095-013-0972-0
Abstract
Most dissolution testing systems rely on analyzing samples taken remotely from the dissolving sample surface at different time points with poor time resolution and therefore provide relatively unresolved temporally and spatially information on the dissolution process. In this study, a flexible numerical model was combined with a novel UV imaging system, allowing monitoring of the dissolution process with sub second time resolution.Keywords
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