Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion
- 1 January 2007
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Cardiovascular Journal
- Vol. 41 (1), 44-50
- https://doi.org/10.1080/14017430601071849
Abstract
Objectives. To find the time-to-peak for creatine kinase MBmass (CKMB) and cardiac troponin T (cTnT) after acute reperfusion, to compare peak and cumulative values to estimate infarct size (IS), and to evaluate clinical routine sampling for assessment of IS. Design. Acute primary percutaneous coronary intervention (PCI) was performed in 38 patients with first-time myocardial infarction. In 21 patients, CKMB and cTnT were acquired before PCI and at 1.5, 3, 6, 12, 18, 24, and 48 hours thereafter. In 17 patients, clinical routine samples were acquired at arrival, and at 10 and 20 h. IS was assessed by delayed contrast-enhanced MRI (DE- MRI). Results. Time-to-peak was 7.6 +/- 3.6 h for CKMB and 8.1 +/- 3.4 h for cTnT. Peak values correlated strongly to cumulative values (r(s) = 0.97-0.98) as well as to DE-MRI (r(s) = 0.8 - 0.82). Clinical routine sampling showed lower r(s) values (0.47 - 0.60). Conclusions. Peak values are likely captured if CKMB and cTnT are acquired at 3, 6, and 12 h after acute PCI. These peak values can be used to estimate myocardial infarct size after acute PCIKeywords
This publication has 20 references indexed in Scilit:
- Gadolinium delayed enhancement cardiovascular magnetic resonance correlates with clinical measures of myocardial infarctionJournal of the American College of Cardiology, 2004
- Measurement of the Gadopentetate Dimeglumine Partition Coefficient in Human Myocardium in Vivo: Normal Distribution and Elevation in Acute and Chronic InfarctionRadiology, 2001
- Measurement of the Distribution Volume of Gadopentetate Dimeglumine at Echo-planar MR Imaging to Quantify Myocardial Infarction: Comparison with99mTc-DTPA Autoradiography in RatsRadiology, 1999
- Reperfused myocardial infarctions on T1‐ and susceptibility‐enhanced MRI: Evidence for loss of compartmentalization of contrast mediaMagnetic Resonance in Medicine, 1994
- Measurement of the extraction efficiency and distribution volume for Gd‐DTPA in normal and diseased canine myocardiumMagnetic Resonance in Medicine, 1993
- Comparison of magnetic resonance imaging studies with enzymatic indexes of myocardial necrosis for quantification of myocardial infarct sizeThe American Journal of Cardiology, 1993
- Effects of reperfusion and superoxide dismutase on myocardial infarct size in a closed chest pig modelCardiovascular Research, 1992
- Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarctionThe American Journal of Cardiology, 1991
- Estimation of circulatory parameters in patients with acute myocardial infarction. Significance for calculation of enzymatic infarct sizeCardiovascular Research, 1979
- Estimation of Infarct Size in Man and its Relation to PrognosisCirculation, 1972