A reevaluation of integrins as regulators of angiogenesis
- 1 September 2002
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 8 (9), 918-921
- https://doi.org/10.1038/nm0902-918
Abstract
Pharmacological agents directed against the integrins αvβ3 and αvβ5 have been reported to inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail to block angiogenesis and in some cases even enhance it. This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists.Keywords
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