Duration of Preventive Antibiotic Administration for Open Extremity Fractures
- 1 March 1988
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 123 (3), 333-339
- https://doi.org/10.1001/archsurg.1988.01400270067010
Abstract
• The necessary duration of antibiotic administration after open fracture has not been established. In a double-blind prospective trial we randomized 248 patients with open fractures to receive one or five days of cefonicid sodium therapy or five days of cefamandole nafate therapy as part of the initial treatment. Rates of fracture-associated infections in the three groups were ten (13%) of 79, ten (12%) of 85, and 11 (13%) of 84, respectively. The 95% confidence limit for the difference in infection rates between the one-day group and the combined five-day groups was 0% to 8.3%. The actual difference was 0.2%. A brief course of antibiotic administration is not inferior to a prolonged course of antibiotics for prevention of postoperative fracture-site infections. (Arch Surg 1988;123:333-339)This publication has 12 references indexed in Scilit:
- Infectious Morbidity in Extremity FracturesJournal Of Trauma-Injury Infection and Critical Care, 1986
- Management of open fractures in the multiple trauma patientWorld Journal of Surgery, 1983
- Antimicrobial Prophylaxis: A Critique of Recent TrialsClinical Infectious Diseases, 1980
- A study of antimicrobial misuse in a university hospitalThe American Journal of the Medical Sciences, 1978
- Open fractures of the tibiaThe Journal of Bone & Joint Surgery, 1978
- Prophylactic Antibiotics Against Early and late Deep Infections after total Hip ReplacementsActa Orthopaedica, 1977
- Resistance of the surgical wound to antimicrobial prophylaxis and its mechanisms of developmentThe American Journal of Surgery, 1973
- PROPHYLACTIC ANTIBIOTICS IN PENETRATING WOUNDS OF THE ABDOMENThe Journal of Trauma and Acute Care Surgery, 1972
- Antibiotic-induced SuprainfectionThe Journal of Infectious Diseases, 1969
- Infections Occurring during ChemotherapyNew England Journal of Medicine, 1954