EGFET-Based Sensors for Bioanalytical Applications: A Review
Open Access
- 19 November 2018
- Vol. 18 (11), 4042
- https://doi.org/10.3390/s18114042
Abstract
Since the 1970s, a great deal of attention has been paid to the development of semiconductor-based biosensors because of the numerous advantages they offer, including high sensitivity, faster response time, miniaturization, and low-cost manufacturing for quick biospecific analysis with reusable features. Commercial biosensors have become highly desirable in the fields of medicine, food, and environmental monitoring as well as military applications, whereas increasing concerns about food safety and health issues have resulted in the introduction of novel legislative standards for these sensors. Numerous devices have been developed for monitoring biological processes such as nucleic acid hybridization, protein–protein interaction, antigen–antibody bonds, and substrate–enzyme reactions, just to name a few. Since the 1980s, scientific interest moved to the development of semiconductor-based devices, which also include integrated front-end electronics, such as the extended-gate field-effect transistor (EGFET) biosensor, one of the first miniaturized chemical sensors. This work is intended to be a review of the state of the art focused on the development of biosensors and chemosensors based on extended-gate field-effect transistor within the field of bioanalytical applications, which will highlight the most recent research reported in the literature. Moreover, a comparison among the diverse EGFET devices will be presented, giving particular attention to the materials and technologies.Keywords
This publication has 159 references indexed in Scilit:
- Prepare dispersed CIS nano-scale particles and spray coating CIS absorber layers using nano-scale precursorsNanoscale Research Letters, 2014
- Redox-potential sensor array based on extended-gate field-effect transistors with ω-ferrocenylalkanethiol-modified gold electrodesSensors and Actuators B: Chemical, 2013
- A Novel Instrumentation Circuit for Electrochemical MeasurementsSensors, 2012
- Self-Assembled Films of Dendrimers and Metallophthalocyanines as FET-Based Glucose BiosensorsSensors, 2011
- Investigation of a Photoelectrochemical Passivated ZnO-Based Glucose BiosensorSensors, 2011
- Optimization of Urea-EnFET Based on Ta2O5 Layer with Post AnnealingSensors, 2011
- Microfabricated Reference Electrodes and their Biosensing ApplicationsSensors, 2010
- A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl esterJournal of Immunological Methods, 2009
- Effect of pH on the Interaction of Gold Nanoparticles with DNA and Application in the Detection of Human p53 Gene MutationNanoscale Research Letters, 2008
- Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosisOncogene, 2008