Studies of the stability and toxicity of zinc polyacrylate (polycarboxylate) cements (PAZ)

Abstract

Zinc polycarboxylate cement (PAZ) was shown to actively bond to ⁴⁵Ca in vitro, with maximum uptake occurring at a Ca⁺² concentration of 0.2 mg/ml. When the resultant PAZ-⁴⁵Ca complex was subsequently incubated in the presence of high levels of unlabeled Ca⁺², there was an exchange between the ⁴⁵Ca bond to the cement and the Ca⁺² in solution. When PAZ prepared using ⁶⁵Zn was incubated with high levels of Ca⁺², there was no exchange between the Ca and the ⁶⁵Zn. ¹⁴C-PA failed to be taken up by L-cells in tissue culture, during 16 division cycles. Using radioactive PAZ prepared from ¹⁴C-PA, the PA moiety of the cement was shown to be extremely insoluble and stable in vivo.