First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer
- 20 October 2017
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 35 (30), 3391-3400
- https://doi.org/10.1200/jco.2017.73.3246
Abstract
PurposeEndoxifen is a tamoxifen metabolite with potent antiestrogenic activity.Patients and MethodsWe performed a phase I study of oral Z-endoxifen to determine its toxicities, maximum tolerated do...Keywords
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