Somatic Mutations ofIDH1andIDH2in the Leukemic Transformation of Myeloproliferative Neoplasms
- 28 January 2010
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 362 (4), 369-370
- https://doi.org/10.1056/nejmc0910063
Abstract
To the Editor: Somatic mutations affecting the R132 residue of isocitrate dehydrogenase 1 (IDH1) and the homologous IDH2 R172 occur in central nervous system tumors.1,2 Recently (in the Sept. 10 issue of the Journal 3), alterations of IDH1 R132 (in exon 2) were reported in 16 of 188 patients with de novo acute myeloid leukemia, with a strong association with a normal karyotype; however, mutations of IDH2 R172 (in exon 4) were not detected. We sequenced exon 2 of the IDH1 gene and exon 4 of the IDH2 gene in patients with leukemia that had evolved from . . .Keywords
This publication has 5 references indexed in Scilit:
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia GenomeThe New England Journal of Medicine, 2009
- IDH1andIDH2Mutations in GliomasThe New England Journal of Medicine, 2009
- Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clonesBritish Journal of Haematology, 2009
- An Integrated Genomic Analysis of Human Glioblastoma MultiformeScience, 2008
- Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformationBlood, 2006