Lifestyle, Diet, and Colorectal Cancer Risk According to (Epi)genetic Instability: Current Evidence and Future Directions of Molecular Pathological Epidemiology
Open Access
- 2 December 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in Current Colorectal Cancer Reports
- Vol. 13 (6), 455-469
- https://doi.org/10.1007/s11888-017-0395-0
Abstract
Purpose of Review In this review, we describe molecular pathological epidemiology (MPE) studies from around the world that have studied diet and/or lifestyle factors in relation to molecular markers of (epi)genetic pathways in colorectal cancer (CRC), and explore future perspectives in this realm of research. The main focus of this review is diet and lifestyle factors for which there is evidence for an association with CRC as identified by the World Cancer Research Fund reports. In addition, we review promising hypotheses, that warrant consideration in future studies. Recent Findings Associations between molecular characteristics of CRC have been published in relation to smoking, alcohol consumption; body mass index (BMI); waist:hip ratio; adult attained height; physical activity; early life energy restriction; dietary acrylamide, fiber, fat, methyl donors, omega 3 fatty acids; meat, including total protein, processed meat, and heme iron; and fruit and vegetable intake. Summary MPE studies help identify where associations between diet, lifestyle, and CRC risk may otherwise be masked and also shed light on how timing of exposure can influence etiology. Sample size is often an issue, but this may be addressed in the future by pooling data.Keywords
Funding Information
- Maastricht University
This publication has 73 references indexed in Scilit:
- Developmental and Functional Expression of miRNA-Stability Related Genes in the Nervous SystemPLOS ONE, 2013
- A colorectal cancer classification system that associates cellular phenotype and responses to therapyNature Medicine, 2013
- Comprehensive molecular characterization of human colon and rectal cancerNature, 2012
- Cigarette Smoking and Colorectal Cancer Risk by KRAS Mutation Status Among Older WomenThe American Journal of Gastroenterology, 2012
- The CpG island methylator phenotype in colorectal cancer: Progress and problemsBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012
- Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet–gene interactions and promoter CpG island hypermethylation in colorectal cancerCancer Causes & Control, 2010
- Somatic alterations, metabolizing genes and smoking in rectal cancerInternational Journal of Cancer, 2009
- Smoking and Colorectal CancerJAMA, 2008
- Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: Results from the Netherlands Cohort StudyMutation Research/Genetic Toxicology and Environmental Mutagenesis, 2008
- Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genesCancer Causes & Control, 2007