Review article: dietary fibre-microbiota interactions
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Open Access
- 24 May 2015
- journal article
- review article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 42 (2), 158-179
- https://doi.org/10.1111/apt.13248
Abstract
Application of modern rapid DNA sequencing technology has transformed our understanding of the gut microbiota. Diet, in particular plant‐based fibre, appears critical in influencing the composition and metabolic activity of the microbiome, determining levels of short‐chain fatty acids (SCFAs) important for intestinal health. To assess current epidemiological, experimental and clinical evidence of how long‐term and short‐term alterations in dietary fibre intake impact on the microbiome and metabolome. A Medline search including items ‘intestinal microbiota’, ‘nutrition’, ‘diet’, ‘dietary fibre’, ‘SCFAs’ and ‘prebiotic effect’ was performed. Studies found evidence of fibre‐influenced differences in the microbiome and metabolome as a consequence of habitual diet, and of long‐term or short‐term intervention (in both animals and humans). Agrarian diets high in fruit/legume fibre are associated with greater microbial diversity and a predominance of Prevotella over Bacteroides. ‘Western’‐style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant‐derived polysaccharides to SCFAs and increase mucosa‐associated Proteobacteria (including enteric pathogens). Short‐term diets can also have major effects, particularly those exclusively animal‐based, and those high‐protein, low‐fermentable carbohydrate/fibre ‘weight‐loss’ diets, increasing the abundance of Bacteroides and lowering Firmicutes, with long‐term adherence to such diets likely increasing risk of colonic disease. Interventions to prevent intestinal inflammation may be achieved with fermentable prebiotic fibres that enhance beneficial Bifidobacteria or with soluble fibres that block bacterial–epithelial adherence (contrabiotics). These mechanisms may explain many of the differences in microbiota associated with long‐term ingestion of a diet rich in fruit and vegetable fibre.Keywords
Funding Information
- Biotechnology and Biological Sciences Research Council (BB/I016783/1)
This publication has 122 references indexed in Scilit:
- An Altered Gut Microbiome Profile in a Child Affected by Crohn's Disease Normalized After Nutritional TherapyThe American Journal of Gastroenterology, 2013
- Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogensThe Journal of Nutritional Biochemistry, 2013
- Diet-Microbiota Interactions and Their Implications for Healthy LivingNutrients, 2013
- Computational meta'omics for microbial community studiesMolecular Systems Biology, 2013
- Metabolic Profiling of the Impact of Oligofructose-Enriched Inulin in Crohn's Disease Patients: A Double-Blinded Randomized Controlled TrialClinical and Translational Gastroenterology, 2013
- Genomic approaches to studying the human microbiotaNature, 2012
- Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− miceNature, 2012
- Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel diseaseInflammatory Bowel Diseases, 2012
- Unveiling an abundant core microbiota in the human adult colon by a phylogroup-independent searching approachThe ISME Journal, 2010
- Dominant and diet-responsive groups of bacteria within the human colonic microbiotaThe ISME Journal, 2010