Hydrogen–Deuterium Exchange Reactions of Aromatic Compounds and Heterocycles by NaBD4‐Activated Rhodium, Platinum and Palladium Catalysts
- 6 October 2009
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 15 (40), 10397-10404
- https://doi.org/10.1002/chem.200901107
Abstract
Conventional thermal and microwave conditions were compared for hydrogen–deuterium (H/D) exchange reactions of aminobenzoic acids catalysed by NaBD4-activated Pd/C or RhCl3 with D2O as the deuterium source. We also investigated different NaBD4-activated metal catalysts (including Pd/C, RhCl3 and Pt/C) under microwave conditions for an efficient H/D exchange of aromatic and heterocyclic compounds. Even higher deuterium incorporations were obtained for Pd/C and Pt/C catalyst mixtures due to the previously observed synergistic effect. Finally, we have applied these optimised conditions for one-step syntheses of the MS standards of several pharmaceutically active compounds.Keywords
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