Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.
Open Access
- 1 September 1990
- journal article
- Published by Informa UK Limited in Molecular and Cellular Biology
- Vol. 10 (9), 4967-4969
- https://doi.org/10.1128/mcb.10.9.4967
Abstract
Treatment of cultured human skin fibroblasts with near-UV radiation, hydrogen peroxide, and sodium arsenite induces accumulation of heme oxygenase mRNA and protein. In this study, these treatments led to a dramatic increase in the rate of RNA transcription from the heme oxygenase gene but had no effect on mRNA stability. Transcriptional activation, therefore, appears to be the major mechanism of stimulation of expression of this gene by either oxidative stress or sulfydryl reagents.Keywords
This publication has 19 references indexed in Scilit:
- Transcriptional Activation of the Heme Oxygenase Gene by Heme and Cadmium in Mouse Hepatoma CellsJournal of Biological Chemistry, 1989
- Structural organization of the human heme oxygenase gene and the function of its promoterEuropean Journal of Biochemistry, 1989
- Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.Proceedings of the National Academy of Sciences of the United States of America, 1989
- Antioxidant protection by haemopexin of haem-stimulated lipid peroxidationBiochemical Journal, 1988
- Human heme oxygenase cDNA and induction of its mRNA by heminEuropean Journal of Biochemistry, 1988
- Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts.Journal of Biological Chemistry, 1987
- Transcriptional control of rat heme oxygenase by heat shock.Journal of Biological Chemistry, 1987
- Bilirubin Is an Antioxidant of Possible Physiological ImportanceScience, 1987
- The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
- Transcriptional regulation of hemoglobin switching in chicken embryos.Molecular and Cellular Biology, 1981