EFFICACY OF NITROGLYCERINE INFUSION VERSUS SUBLINGUAL NIFEDIPINE IN SEVERE PRE‐ECLAMPSIA: A RANDOMIZED, TRIPLE‐BLIND, CONTROLLED TRIAL
- 7 December 2007
- journal article
- research article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 35 (5-6), 580-585
- https://doi.org/10.1111/j.1440-1681.2007.04838.x
Abstract
1. Information regarding the use of continuous i.v. administration of nitroglycerine as an antihypertensive agent in the management of pre-eclampsia is scarce. In the present study, i.v. nitroglycerine or sublingual nifedipine were administered to 32 women with severe pre-eclampsia who were being managed with controlled plasma volume expansion and MgSO(4) loading and maintenance doses. Maternal blood pressure and heart rate responses, fetal heart rate responses and perinatal fetal-maternal adverse effects were evaluated using classical parametric and non-parametric data analysis and data modelling by mixed models. 2. An important hypotensive response was observed in both groups, although this reponse was greater, faster and exhibited less variability (more precision) in the nitroglycerine-treated group. Heart rate also increased in both the nitroglycerine- and nifedipine-treated groups (4.6 +/- 4.4 vs 8.6 +/- 5.3 b.p.m., respectively), although the increase in the nifedipine-treated group was almost twofold that in the nitroglycerine-treated group. There were no significant changes in fetal heart rate in response to vasodilator therapy. The frequency of perinatal fetal-maternal adverse effects was similar in both groups at 40% and the adverse effects observed included flushing, headache, palpitations and nausea. 3. In conclusion, i.v. infusion of nitroglycerine is an effective, safe and alternative therapy for severe pre-eclampsia.Keywords
This publication has 25 references indexed in Scilit:
- Glyceryl Trinitrate Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in the Syncytiotrophoblast of the Human Placenta: Therapeutic Implications for PreeclampsiaThe American Journal of Pathology, 2007
- Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsiaAmerican Journal of Obstetrics and Gynecology, 2005
- Nitroglycerin for Relaxation to Establish a Fetal Airway (EXIT Procedure)Obstetrics & Gynecology, 2004
- The Effect of Glyceryl Trinitrate on Hypertension in Women with Severe Preeclampsia, HELLP Syndrome, and EclampsiaHypertension in Pregnancy, 2004
- Evaluation of the Method for Nifedipine Administration for a Rapid Onset of Clinical Effect: A Clinical Study in Normal Volunteers.YAKUGAKU ZASSHI, 2001
- The detection, investigation and management of hypertension in pregnancy: executive summaryAustralian and New Zealand Journal of Obstetrics and Gynaecology, 2000
- Forming inferences about some intraclass correlation coefficients.Psychological Methods, 1996
- Forming inferences about some intraclass correlation coefficients.Psychological Methods, 1996
- The Effects of Nitroglycerin on Cerebrospinal Fluid Pressure in Awake and Anesthetized HumansAnesthesiology, 1981