The Dectin-2 family of C-type lectin-like receptors: an update
Open Access
- 12 April 2013
- journal article
- review article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 25 (5), 271-277
- https://doi.org/10.1093/intimm/dxt006
Abstract
Myeloid and non-myeloid cells express members of the C-type lectin-like receptor (CTLR) family, which mediate crucial cellular functions during immunity and homeostasis. Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell immunoactivating receptor (DCAR), dendritic cell immunoreceptor (DCIR), Dectin-2, C-type lectin superfamily 8 (CLECSF8) and macrophage-inducible C-type lectin (Mincle). These CTLRs possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules. These receptors recognize a diverse range of endogenous and exogenous ligands, and can function as pattern recognition receptors for several classes of pathogens including fungi, bacteria and parasites, driving both innate and adaptive immunity. In this review, we summarize our knowledge of each of these receptors, highlighting the exciting discoveries that have been made in recent years.Keywords
This publication has 69 references indexed in Scilit:
- The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk KinaseOnline Journal of Public Health Informatics, 2012
- Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate ImmunityImmunity, 2012
- Human C-type Lectin Domain Family 4, Member C (CLEC4C/BDCA-2/CD303) Is a Receptor for Asialo-galactosyl-oligosaccharides*Journal of Biological Chemistry, 2011
- Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the SkinCell Host & Microbe, 2011
- Schistosomamansonitriggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responsesProceedings of the National Academy of Sciences of the United States of America, 2010
- Pathways Regulating Cytosolic Phospholipase A2 Activation and Eicosanoid Production in Macrophages by Candida albicansOnline Journal of Public Health Informatics, 2010
- CARD9 Mediates Dectin-2-induced IκBα Kinase Ubiquitination Leading to Activation of NF-κB in Response to Stimulation by the Hyphal Form of Candida albicansOnline Journal of Public Health Informatics, 2010
- The Dectin-2 family of C-type lectins in immunity and homeostasisCytokine, 2009
- C-type lectin Mincle is an activating receptor for pathogenic fungus,MalasseziaProceedings of the National Academy of Sciences of the United States of America, 2009
- HIV-1 gp120 inhibits TLR9-mediated activation and IFN-α secretion in plasmacytoid dendritic cellsProceedings of the National Academy of Sciences of the United States of America, 2007