Simplified data access on human skeletal muscle transcriptome responses to differentiated exercise
Open Access
- 25 November 2014
- journal article
- dataset
- Published by Springer Science and Business Media LLC in Scientific Data
- Vol. 1 (1), 140041
- https://doi.org/10.1038/sdata.2014.41
Abstract
Few studies have investigated exercise-induced global gene expression responses in human skeletal muscle and these have typically focused at one specific mode of exercise and not implemented non-exercise control models. However, interpretation on effects of differentiated exercise necessitate direct comparison between essentially different modes of exercise and the ability to identify true exercise effect, necessitate implementation of independent non-exercise control subjects. Furthermore, muscle transcriptome data made available through previous exercise studies can be difficult to extract and interpret by individuals that are inexperienced with bioinformatics procedures. In a comparative study, we therefore; (1) investigated the human skeletal muscle transcriptome responses to differentiated exercise and non-exercise control intervention, and; (2) set out to develop a straightforward search tool to allow for easy access and interpretation of our data. We provide a simple-to-use spread sheet containing transcriptome data allowing other investigators to easily see how mRNA of their gene(s) of interest behave in skeletal muscle following exercise, both endurance, resistance and non-exercise, to better aid hypothesis-driven question in this field of research.Keywords
This publication has 29 references indexed in Scilit:
- Pronounced Effects of Acute Endurance Exercise on Gene Expression in Resting and Exercising Human Skeletal MusclePLOS ONE, 2012
- Resistance exercise training influences skeletal muscle immune activation: a microarray analysisJournal of Applied Physiology, 2012
- Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training‐accustomed individualsScandinavian Journal of Medicine & Science in Sports, 2011
- Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary proteinPhysiological Genomics, 2011
- A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle HypertrophyMolecular Biology of the Cell, 2010
- Eccentric Exercise Activates Novel Transcriptional Regulation of Hypertrophic Signaling Pathways Not Affected by Hormone ChangesPLOS ONE, 2010
- Resistance Exercise BiologySports Medicine, 2008
- The Influence of Frequency, Intensity, Volume and Mode of Strength Training on Whole Muscle Cross-Sectional Area in HumansSports Medicine, 2007
- Akt signalling through GSK‐3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophyThe Journal of Physiology, 2006
- Are exercise‐induced genes induced by exercise?The FASEB Journal, 2004