Ruthenium-Catalyzed Cycloisomerization−6π-Cyclization: A Novel Route to Pyridines
- 16 March 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (8), 1473-1476
- https://doi.org/10.1021/ol070163t
Abstract
Herein we report a method for the synthesis of substituted pyridines. The unsaturated ketones and aldehydes derived from the cycloisomerization of primary and secondary propargyl diynols in the presence of [CpRu(CH3CN)3]PF6 (1) are converted to 1-azatrienes which in turn undergo a subsequent electrocyclization−dehydration to provide pyridines with excellent regiocontrol.Keywords
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