Primary Benign and Malignant Thyroid Neoplasms With Signet Ring Cells
- 1 August 2017
- journal article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 148 (3), 251-258
- https://doi.org/10.1093/ajcp/aqx074
Abstract
Signet ring cells (SRCs) can be seen in a variety of thyroid tumors and can pose a diagnostic pitfall on cytology. This study describes the cytologic, histomorphologic, and molecular aspects of a cohort of primary thyroid tumors with SRCs. A search was performed of the Massachusetts General Hospital and Brigham and Women’s Hospital (Boston, MA) pathology archives for the keywords thyroid, signet, and signet ring features between 2000 and 2014. Seven thyroidectomy specimens with corresponding thyroid fine-needle aspiration (FNA) were obtained. Cytology and histopathology slides were evaluated. Molecular analysis was performed using anchored multiplex polymerase chain reaction (AMP). The cohort consisted of four follicular adenomas (FAs), two noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTPs), and one secretory carcinoma (SC). The FNA diagnoses were atypia of undetermined significance (n = 3), suspicious for follicular neoplasm (n = 3), and suspicious for malignancy (n = 1). Molecular analyses revealed PTEN and FGFR3 mutations in an FA and NIFTP, respectively, and an ETV6-NTRK3 fusion in a case of primary thyroid gland SC. Our study demonstrates the range of thyroid tumors with SRCs. While most thyroid tumors with SRCs are benign, primary thyroid SC should also be considered in the differential diagnosis.Keywords
This publication has 38 references indexed in Scilit:
- The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell CarcinomaPLOS ONE, 2016
- Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center DatabasePLOS ONE, 2015
- Morphological features and mucin expression profile of breast carcinomas with signet-ring cell differentiationPathology - Research and Practice, 2015
- Fine-Needle Aspiration of Mucin-Producing Thyroid TumorsActa Cytologica, 2011
- Mucin-producing signet ring cell adenoma of the thyroidIndian Journal of Pathology and Microbiology, 2008
- Signet Ring Cells in a Poorly Differentiated Hurthle Cell Carcinoma of the Thyroid Combined With Two Papillary MicrocarcinomasInternational Journal of Surgical Pathology, 2007
- Signet-Ring Follicular Adenoma of the Thyroid Diagnosed by Fine Needle AspirationActa Cytologica, 2004
- Signet Ring Cell Adenoma of the Thyroid with Mucin PredominanceThyroid®, 1999
- Clear cell change in primary thyroid tumorsThe American Journal of Surgical Pathology, 1985
- Signet-ring-cell thyroid tumorsThe American Journal of Surgical Pathology, 1985