Multiregional brain iron deficiency in restless legs syndrome
- 28 April 2008
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 23 (8), 1184-1187
- https://doi.org/10.1002/mds.22070
Abstract
Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS patients and 19 controls and correlated them with sonographically assessed SN echogenicity. Both neuroimaging features are supposed to correlate with tissue iron content. Mean T2 values of all regions were higher in patients (2.9–7.8%), though significantly increased only in four regions; the mean T2 over all voxels was higher in patients (5.1%, P < 0.001) and correlated inversely with SN echogenicity (r = −0.61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. © 2008 Movement Disorder SocietyKeywords
This publication has 15 references indexed in Scilit:
- Substantia nigra hypoechogenicity: Definition and findings in restless legs syndromeMovement Disorders, 2006
- Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndromeAnnals of Neurology, 2005
- The role of opioids in restless legs syndrome: an [11C]diprenorphine PET studyBrain, 2005
- Neuropathological examination suggests impaired brain iron acquisition in restless legs syndromeNeurology, 2003
- Restless legs syndrome: diagnostic criteria, special considerations, and epidemiologySleep Medicine, 2003
- MRI measurement of brain iron in patients with restless legs syndromeNeurology, 2001
- Neuroimaging in basal ganglia disorders: Perspectives for transcranial ultrasoundMovement Disorders, 2001
- Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndromeNeurology, 2000
- Cerebral generators involved in the pathogenesis of the restless legs syndromeAnnals of Neurology, 1997
- Toward a better definition of the restless legs syndromeMovement Disorders, 1995