Fungal natural products in research and development
- 14 August 2014
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Natural Product Reports
- Vol. 31 (10), 1425-1448
- https://doi.org/10.1039/c4np00060a
Abstract
Covering: 2009 to 2013 To date approximately 100 000 fungal species are known although far more than one million are expected. The variety of species and the diversity of their habitats, some of them less exploited, allow the conclusion that fungi continue to be a rich source of new metabolites. Besides the conventional fungal isolates, an increasing interest in endophytic and in marine-derived fungi has been noticed. In addition new screening strategies based on innovative chemical, biological, and genetic approaches have led to novel fungal metabolites in recent years. The present review focuses on new fungal natural products published from 2009 to 2013 highlighting the originality of the structures and their biological potential. Furthermore synthetic products based on fungal metabolites as well as new developments in the uses or the biological activity of known compounds or new derivatives are discussed.Keywords
This publication has 100 references indexed in Scilit:
- Drimane Sesquiterpenoids from Marasmius sp. Inhibiting the Conidial Germination of Plant-Pathogenic FungiJournal of Natural Products, 2012
- Identification and Characterization of the Echinocandin B Biosynthetic Gene Cluster from Emericella rugulosa NRRL 11440Journal of the American Chemical Society, 2012
- Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decadesActa Pharmacologica Sinica, 2012
- Liver X receptor biology and pharmacology: new pathways, challenges and opportunitiesTrends in Pharmacological Sciences, 2012
- Waikialoid A Suppresses Hyphal Morphogenesis and Inhibits Biofilm Development in Pathogenic Candida albicansJournal of Natural Products, 2012
- Fungal secondary metabolites – Strategies to activate silent gene clustersFungal Genetics and Biology, 2011
- Four New Alkaloids, Brevianamides O – R, from the Fungus Aspergillus versicolorHelvetica Chimica Acta, 2010
- Chemical Epigenetics Alters the Secondary Metabolite Composition of Guttate Excreted by an Atlantic-Forest-Soil-Derived Penicillium citreonigrumJournal of Natural Products, 2010
- Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complexBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
- U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:: The Structures of Tiamulin, Homoharringtonine, and Bruceantin Bound to the RibosomeJournal of Molecular Biology, 2009