The efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation
Open Access
- 2 June 1998
- journal article
- Published by Frontiers Media SA in Transplant International
- Vol. 11 (s1), S390-S392
- https://doi.org/10.1111/j.1432-2277.1998.tb01164.x
Abstract
One of the most common complications after liver transplantation is primary graft dysfunction which results from severe deterioration of the microcirculation. The data obtained from our experimental studies indicate that N‐acetylcysteine (NAC) is able to reduce the severity of ischemia/reperfusion injury and improves postoperative graft function after liver transplantation in rats. The aim of this pilot study was to evaluate the efficacy of NAC as a hepatoprotective agent under clinical conditions. A group of 30 liver transplanted patients were treated with NAC, and 30 patients (control group) were treated with a 5 % solution of glucose only. In the NAC group we observed a distinct reduction in ischemia/reperfusion injury and improved liver function with less elevated peak transaminases, better macrocirculation, improved liver synthesis function and a lower incidence of primary nonfunction compared with the control group. We conclude that NAC is a very promising substance for reducing graft dysfunction in clinical liver transplantation.Keywords
This publication has 6 references indexed in Scilit:
- Efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation: An experimental studyTransplantation Proceedings, 1997
- Clinical biology of nitric oxideBritish Journal of Surgery, 1995
- A Prospective Study Of Fk506 Versus Csa And Pig Atg In A Porcine Model Of Small Bowel TransplantationTransplantation, 1995
- IN VIVO IgM DEPLETION BY ANTI-μ MONOCLONAL ANTIBODY THERAPYTransplantation, 1994
- N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.Circulation Research, 1989
- N-acetylcysteine inhibits human neutrophil and monocyte chemotaxis and oxidative metabolismInternational Journal of Immunopharmacology, 1988