Atrial natriuretic factor—a circulating hormone stimulated by volume loading
- 1 March 1985
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 314 (6008), 264-266
- https://doi.org/10.1038/314264a0
Abstract
The cardiocytes of mammalian cardiac atria contain granules very similar to those in endocrine cells. The number of these atrial granules is related directly to salt loading and blood volume. Furthermore, crude extracts of rat atria and granule preparations have powerful natriuretic and diuretic effects. These effects are mediated by peptides identified previously as atrial natriuretic factor (ANF). The peptides are derived from a common precursor, whose structure has been elucidated recently. Although there is indirect evidence from morphological studies that at least some of these peptides may be released into the blood and function as hormones, their presence in the blood has not yet been demonstrated. Here we describe a sensitive and specific radioimmunoassay for ANF and its stimulation on volume loading.Keywords
This publication has 14 references indexed in Scilit:
- The Structure of Rat Preproatrial Natriuretic Factor as Defined by a Complementary DNA CloneScience, 1984
- Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic poly peptideNature, 1984
- Structure of rat atrial natriuretic factor precursor deduced from cDNA sequenceNature, 1984
- Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptideNature, 1984
- Identification in rat atrial tissue of multiple forms of natriuretic polypeptides of about 3,000 daltonsBiochemical and Biophysical Research Communications, 1984
- Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.Proceedings of the National Academy of Sciences, 1984
- Atriopeptins: A family of potent biologically active peptides derived from mammalian atriaBiochemical and Biophysical Research Communications, 1984
- Purification and complete amino acid sequence of beta-rat atrial natriuretic polypeptide (β-rANP) of 5,000 daltonsBiochemical and Biophysical Research Communications, 1984
- The amino acid sequence of an atrial peptide with potent diuretic and natriuretic propertiesBiochemical and Biophysical Research Communications, 1983
- Relationship of specific granules to the natriuretic and diuretic activity of rat atriaCellular and Molecular Life Sciences, 1982