Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer
Open Access
- 19 November 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 8 (1), 1-12
- https://doi.org/10.1038/s41598-018-35354-y
Abstract
Luminescence nanothermometry has attracted much attention as a non-contact thermal sensing technique. However, it is not widely explored for in vivo applications owing to the low transparency of tissues for the light to be used. In this study, we performed biological temperature sensing in deep tissues using β-NaYF4 nanoparticles co-doped with Yb3+, Ho3+, and Er3+ (NaYF4: Yb3+, Ho3+, Er3+ NPs), which displayed two emission peaks at 1150 nm (Ho3+) and 1550 nm (Er3+) in the >1000 nm near-infrared wavelength region, where the scattering and absorption of light by biological tissues are at the minimum. The change in the luminescence intensity ratio of the emission peaks of Ho3+ and Er3+ (IHo/IEr) in the NaYF4: Yb3+, Ho3+, Er3+ nanothermometer differs corresponding to the thickness of the tissue. Therefore, the relationship between IHo/IEr ratio and temperature needs to be calibrated by the depth of the nanothermometer. The temperature-dependent change in the IHo/IEr was evident at the peritoneal cavity level, which is deeper than the subcutaneous tissue level. The designed experimental system for temperature imaging will open the window to novel luminescent nanothermometers for in vivo deep tissue temperature sensing.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science, and Technology (15H05950, 16H04499, 15K14131, S1511012)
This publication has 47 references indexed in Scilit:
- Luminescent probes and sensors for temperatureChemical Society Reviews, 2013
- Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopyNature Communications, 2012
- Simultaneous phase and size control of upconversion nanocrystals through lanthanide dopingNature, 2010
- Second window for in vivo imagingNature Nanotechnology, 2009
- Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical ImpactAccounts of Chemical Research, 2008
- Effect of temperature variation on the visible and near infrared spectra of wine and the consequences on the partial least square calibrations developed to measure chemical compositionAnalytica Chimica Acta, 2007
- Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeonsJournal of Biomedical Optics, 2006
- The Optics of Human SkinJournal of Investigative Dermatology, 1981
- Agar‐Gel Electrophoretic and Analytic Agar‐Gel Electrophoretic Study of BromelinTransfusion, 1964
- Thermodynamics of Biological GrowthNature, 1962