COX‐1 and ‐2 activity of rose hip
- 18 July 2007
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 21 (12), 1251-1252
- https://doi.org/10.1002/ptr.2236
Abstract
The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC50 values of 12 µg/mL for COX-1 and 19 µg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase. Copyright © 2007 John Wiley & Sons, Ltd.Keywords
This publication has 6 references indexed in Scilit:
- The evidence for clinical efficacy of rose hip and seed: a systematic reviewPhytotherapy Research, 2006
- An Antiinflammatory Galactolipid from Rose Hip (Rosa canina) that Inhibits Chemotaxis of Human Peripheral Blood Neutrophils in VitroJournal of Natural Products, 2003
- Cryptocarya species — substitute plants for Ocotea bullata? A pharmacological investigation in terms of cyclooxygenase-1 and -2 inhibitionJournal of Ethnopharmacology, 2000
- Prostaglandin Synthesis Inhibitory Activity in Zulu, Xhosa and Sotho Medicinal PlantsPhytotherapy Research, 1997
- Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitorsJournal of Ethnopharmacology, 1996
- Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosisJournal of Ethnopharmacology, 1995