Enhancement and inhibition of snake venom phosphodiesterase activity by lysophospholipids
Open Access
- 2 October 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 436 (2), 256-258
- https://doi.org/10.1016/s0014-5793(98)01142-9
Abstract
Lysophospholipids are liberated during venomous action. In this study we demonstrated that lysophosphatidyl choline (LPC) of various acyl chains enhances considerably the activity of snake venom phosphodiesterase (PDE). Lysophosphatidic acid (LPA) and its cyclic form (cLPA), on the other hand, were found to inhibit this enzyme in a non‐competitive (LPA) or competitive (cLPA) manner. Both of these activities may contribute to the progression and subsidence of the poisoning profile. PDE from cellular origin was not substantially affected by any of the above lysophospholipids.This publication has 25 references indexed in Scilit:
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