Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients
Open Access
- 1 June 1995
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in Annals of Surgery
- Vol. 221 (6), 721-733
- https://doi.org/10.1097/00000658-199506000-00011
Abstract
This single-institution study examined the outcome after pancreaticoduodenectomy in patients with adenocarcinoma of the head of the pancreas. In recent years, pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas has been associated with decreased morbidity and mortality and, in some centers, 5-year survival rates in excess of 20%. Two hundred one patients with pathologically verified adenocarcinoma of the head of the pancreas undergoing pancreaticoduodenectomy at The Johns Hopkins Hospital between 1970 and 1994 were analyzed (the last 100 resections were performed between March 1991 and April 1994). This is the largest single-institution experience reported to date. The overall postoperative in-hospital mortality rate was 5%, but has been 0.7% for the last 149 patients. The actuarial 5-year survival for all 201 patients was 21%, with a median survival of 15.5 months. There were 11 5-year survivors. Patients resected with negative margins (curative resections: n = 143) had an actuarial 5-year survival rate of 26%, with a median survival of 18 months, whereas those with positive margins (palliative resections: n = 58) fared significantly worse, with an actuarial 5-year survival rate of 8% and a median survival of 10 months (pKeywords
This publication has 42 references indexed in Scilit:
- The Effects of Regionalization on Cost and Outcome for One General High-Risk Surgical ProcedureAnnals of Surgery, 1995
- Clinical highlights from the National Cancer Data Base: 1994CA: A Cancer Journal for Clinicians, 1994
- Resection Margins in Carcinoma of the Head of the PancreasAnnals of Surgery, 1993
- Pylorus-preserving versus standard pancreaticoduodenectomy: an analysis of 110 pancreatic and periampullary carcinomasBritish Journal of Surgery, 1992
- Evaluation of DNA Nuclear Pattern as a Prognostic Determinant in Resected Pancreatic Ductal AdenocarcinomaAnnals of Surgery, 1992
- Pancreatic Cancer Cell DNA Content Correlates With Long-term Survival After PancreatoduodenectomyAnnals of Surgery, 1991
- Pylorus preserving pancreatoduodenectomy: An overviewBritish Journal of Surgery, 1990
- Postprandial Plasma Gastrin and Secretin Concentrations After a PancreatonduodenectomyAnnals of Surgery, 1989
- Regional Pancreatectomy for Cancer of the Pancreas, Ampulla, and Other Related SitesAnnals of Surgery, 1984
- Adenocarcinoma of the PancreasAnnals of Surgery, 1975