Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats
- 23 November 2010
- journal article
- Published by Taylor & Francis Ltd in Bioscience, Biotechnology, and Biochemistry
- Vol. 74 (11), 2310-2312
- https://doi.org/10.1271/bbb.100328
Abstract
The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50=59.9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.Keywords
This publication has 11 references indexed in Scilit:
- The Occurrence of Renin Inhibitor in Rice: Isolation, Identification, and Structure-Function RelationshipBioscience, Biotechnology, and Biochemistry, 2010
- Inhibition of human renin activity by saponinsBiomedical Research, 2010
- Isolation of Human Renin Inhibitor from Soybean: Soyasaponin I Is the Novel Human Renin Inhibitor in SoybeanBioscience, Biotechnology, and Biochemistry, 2008
- High-Level Expression of Recombinant Active Human Renin in Sf-9 Cells: Rapid Purification and CharacterizationBioscience, Biotechnology, and Biochemistry, 2007
- Refolding and Activation of Human Prorenin Expressed inEscherichia coli: Application of Recombinant Human Renin for Inhibitor ScreeningBioscience, Biotechnology, and Biochemistry, 2006
- Aliskiren, a Novel Orally Effective Renin Inhibitor, Provides Dose-Dependent Antihypertensive Efficacy and Placebo-Like Tolerability in Hypertensive PatientsCirculation, 2005
- Renin: origin, secretion and synthesisJournal Of Physiology-London, 2003
- Relationship between Chemical Structures and Biological Activities of Triterpenoid Saponins from SoybeanBioscience, Biotechnology, and Biochemistry, 1998
- Effects of Soyasaponins on Liver Injury Induced by Highly Peroxidized Fat in RatsPlanta Medica, 1984
- Quantitative Determination of Soyasaponins in Soybeans of Various Origins and Soybean Products by Means of High Performance Liquid ChromatographyYAKUGAKU ZASSHI, 1984