The retention of ascorbic acid by guinea-pig tissues
Open Access
- 1 November 1971
- journal article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 26 (3), 433-438
- https://doi.org/10.1079/bjn19710048
Abstract
1. Male and female guinea-pigs with high tissue concentrations of L-xyloascorbic acid (ascorbic acid, AA) and male guinea-pigs with high tissue concentrations of D-araboascorbic acid (isoascorbic acid, isoAA) were given a scorbutogenic diet and the rates of depletino from various tissues were measured fro both isomers.2. The loss of AA from the brain and eye lens was considerably less rapid than the loss from the adrenal glands, spleen and aqueous humour. After 14nd on the AA-free diet the AA concentrations in the brain and eye lens were 24 and 27% respectively of the initial concentrations; the corresponding values for the aqueous humour, adrenal glands and spleen were 3,4 and 5%. There was no apparent sex difference in the rate of loss of AA.3. The loss of isoAA was much more rapid than that of AA in the spleen, adrenal glands and aqueous humour; in the brain and eye lens the depletion patterns of the two isomers were similar.Keywords
This publication has 14 references indexed in Scilit:
- The influence of sex and age on the deposition of L-xyloascorbic acid in tissues of guinea-pigsBritish Journal of Nutrition, 1971
- Turnover rates of D-isoascorbic acid and L-ascorbic acid in guinea pig organsCanadian Journal of Physiology and Pharmacology, 1969
- The uptake of D-araboascorbic acid (D-isoascorbic acid) by guinea-pig tissuesBritish Journal of Nutrition, 1969
- CHRONIC SCURVYBritish Journal of Dermatology, 1968
- Orthomolecular PsychiatryScience, 1968
- The Passage of Vitamin C across the Erythrocyte MembraneBritish Journal of Haematology, 1968
- Antiscorbutic Activity of D-Araboascorbic Acid.Experimental Biology and Medicine, 1967
- The distribution and possible functions of ascorbic acid in the eyeExperimental Eye Research, 1962
- STUDIES ON THE TISSUE DISTRIBUTION OF ASCORBIC ACIDAnnals of the New York Academy of Sciences, 1961
- The use of homocysteine in the estimation of dehydroascorbic acidBiochemical Journal, 1956