Corneal Toxicity of Propamidine

Abstract

• Two patients with Acanthamoeba keratitis developed a corneal abnormality following prolonged treatment with topical 1% propamidine isethionate. In both instances, withdrawal of drug therapy resulted in a gradual clearing of the keratopathy, with no permanent sequelae. The changes we observed may be confused with those of active Acanthamoeba infection.