Acute Hemorrhagic Edema of Infancy: A Troubling Cutaneous Presentation with a Self‐Limiting Course
- 21 November 2012
- journal article
- case report
- Published by Wiley in Pediatric Dermatology
- Vol. 30 (6), e149-e152
- https://doi.org/10.1111/pde.12004
Abstract
Acute hemorrhagic edema of infancy (AHEI) is an unusual form of leukocytoclastic vasculitis with dramatic distinguishing skin lesions that occurs in infants ages 4 to 24 months old. The disease presents with skin eruptions that usually start with large (1-5 cm), symmetrically distributed, hemorrhagic lesions in a characteristic cockade pattern. The lesions are typically located on the lower extremities, face (in particular the ears, cheeks, and eyelids), and gluteal area. Fever may accompany skin eruptions. Clinical presentation at onset requires clinical and laboratory examination to distinguish it from more serious diseases and other vasculitis. The main differential diagnosis of AHEI is Henoch-Schönlein purpura. AHEI is generally a self-limiting disease, so a conservative approach should be considered. Topical or systemic corticosteroid therapy has been reported to be beneficial, as well as antihistamines and dapsone, although AHEI usually resolves completely with or without treatment. We report two cases of AHEI and an update of the literature.Keywords
This publication has 10 references indexed in Scilit:
- Acute hemorrhagic edema of infancy: unusual scarring and review of the English language literatureInternational Journal of Dermatology, 2009
- Acute hemorrhagic edema of young children (cockade purpura and edema): A case series and systematic reviewJournal of the American Academy of Dermatology, 2008
- Acute Hemorrhagic Edema of Infancy: Report of 4 Cases and Review of the Current LiteratureClinical Pediatrics, 2008
- Renal involvement and hypocomplementemia in a patient with acute hemorrhagic edema of infancyPediatric Nephrology, 2007
- Acute infantile hemorrhagic edema and Henoch-Sch?nlein purpura: Is IgA the missing link??Journal of the American Academy of Dermatology, 2002
- Acute Infantile Hemorrhagic Edema and Henoch-Schonlein Purpura Overlap in a ChildPediatric Dermatology, 2002
- Acute haemorrhagic oedema of infancy, a benign variant of leucocytoclastic vasculitisActa Paediatrica, 1996
- Acute hemorrhagic edema of infancy (AHEI)—A variant of Henoch-Schönlein purpura or a distinct clinical entity?Journal of Allergy and Clinical Immunology, 1990
- PURPURA, URTICARIA AND ANGIONEUROTIC EDEMA OF THE HANDS AND FEET IN A NURSING BABYPublished by American Medical Association (AMA) ,1913