Genome-wide association of anthropometric traits in African- and African-derived populations
Open Access
- 16 April 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 19 (13), 2725-2738
- https://doi.org/10.1093/hmg/ddq154
Abstract
Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide analyses of imputed genotype and copy number variants (CNVs) for anthropometric measures in African-derived populations: 1188 Nigerians from Igbo-Ora and Ibadan, Nigeria, and 743 African-Americans from Maywood, IL. To improve the reach of our study, we used imputation to estimate genotypes at ∼2.1 million single-nucleotide polymorphisms (SNPs) and also tested CNVs for association. No SNPs or common CNVs reached a genome-wide significance level for association with height or body mass index (BMI), and the best signals from a meta-analysis of the two cohorts did not replicate in ∼3700 African-Americans and Jamaicans. However, several loci previously confirmed in European populations showed evidence of replication in our GWA panel of African-derived populations, including variants near IHH and DLEU7 for height and MC4R for BMI. Analysis of global burden of rare CNVs suggested that lean individuals possess greater total burden of CNVs, but this finding was not supported in an independent European population. Our results suggest that there are not multiple loci with strong effects on anthropometric traits in African-derived populations and that sample sizes comparable to those needed in European GWA studies will be required to identify replicable associations. Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations.Keywords
This publication has 51 references indexed in Scilit:
- Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat DistributionPLoS Genetics, 2009
- Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame SizePLoS Genetics, 2009
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulationNature Genetics, 2008
- Rare chromosomal deletions and duplications increase risk of schizophreniaNature, 2008
- Many sequence variants affecting diversity of adult human heightNature Genetics, 2008
- Common variants in the GDF5-UQCC region are associated with variation in human heightNature Genetics, 2008
- Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related TraitsPLoS Genetics, 2007
- Association Studies of BMI and Type 2 Diabetes in the Neuropeptide Y PathwayDiabetes, 2007
- Principal components analysis corrects for stratification in genome-wide association studiesNature Genetics, 2006
- Genomic Control for Association StudiesBiometrics, 1999