SPECT Imaging of Epilepsy: An Overview and Comparison with F-18 FDG PET
Open Access
- 14 July 2011
- journal article
- review article
- Published by Hindawi Limited in International Journal of Molecular Imaging
- Vol. 2011, 1-9
- https://doi.org/10.1155/2011/813028
Abstract
Epilepsy surgery is highly effective in treating refractory epilepsy, but requires accurate presurgical localization of the epileptogenic focus. Briefly, localization of the region of seizure onset traditionally dependents on seizure semiology, scalp EEG recordings and correlation with anatomical imaging modalities such as MRI. The introduction of noninvasive functional neuroimaging methods, including single-photon emission computed tomography (SPECT) and positron emission tomography (PET) has dramatically changed the method for presurgical epilepsy evaluation. These imaging modalities have become powerful tools for the investigation of brain function and are an essential part of the evaluation of epileptic patients. Of these methods, SPECT has the practical capacity to image blood flow functional changes that occur during seizures in the routine clinical setting. In this review we present the basic principles of epilepsy SPECT and PET imaging. We discuss the properties of the SPECT tracers to be used for this purpose and imaging acquisition protocols as well as the diagnostic performance of SPECT in addition to SPECT image analysis methods. This is followed by a discussion and comparison to F-18 FDG PET acquisition and imaging analysis methods.Keywords
This publication has 30 references indexed in Scilit:
- Superiority of HMPAO Ictal SPECT to ECD Ictal SPECT in Localizing the Epileptogenic ZoneEpilepsia, 2002
- Ratio-Images Calculated From Interictal Positron Emission Tomography and Single-Photon Emission Computed Tomography for Quantification of the Uncoupling of Brain Metabolism and Perfusion in EpilepsyEpilepsia, 2000
- FDGâPositron Emission Tomography and Invasive EEG: Seizure Focus Detection and Surgical OutcomeEpilepsia, 1997
- Postsurgical Outcome of Patients with Uncontrolled Complex Partial Seizures and Temporal Lobe Hypometabolism on 18FDG-Positron Emission TomographyInvestigative Radiology, 1996
- Comparison of ictal SPECT and interictal PET in the presurgical evaluation of temporal lobe epilepsyAnnals of Neurology, 1995
- Introduction to Imaging Brain Tumor Metabolism with Positron Emission Tomography (PET)Cancer Investigation, 1995
- The Relative Contributions of MRI, SPECT, and PET Imaging in EpilepsyEpilepsia, 1994
- Technetium-99m-d,l-HM-PAO, the Development of a New Class of 99mTc-Labeled Tracers: An OverviewJournal of Cerebral Blood Flow & Metabolism, 1988
- Epilepsy related to cerebral blood flow and metabolismActa Psychiatrica Scandinavica, 1984
- Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3Annals of Neurology, 1980