CHMIS-C: A Comprehensive Herbal Medicine Information System for Cancer
- 9 February 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 48 (5), 1481-1488
- https://doi.org/10.1021/jm049838d
Abstract
A comprehensive herbal medicine information system for cancer (CHMIS-C) has been developed. The current version of the database integrates information on more than 200 anticancer herbal recipes that have been used for the treatment of different types of cancer in clinic, 900 individual ingredients, and 8500 small organic molecules isolated from herbal medicines. Furthermore, subsidiary databases of literature references and molecular targets have been constructed. A number of web-based searching tools have been developed and integrated into the information system for efficient data mining. The compounds in the database have been linked to the corresponding entries in the National Cancer Institute's database, and to a database of drugs approved by the U.S. Food and Drug Administration. This paper provides a description of the individual subsidiary databases, integration of the entire database, and data mining tools. We demonstrate that this comprehensive information system may be used as an effective informatics tool for anticancer drug discovery.Keywords
This publication has 9 references indexed in Scilit:
- A Web-Based 3D-Database Pharmacophore Searching Tool for Drug DiscoveryJournal of Chemical Information and Computer Sciences, 2002
- Herbal Medicines Today and the Roots of Modern PharmacologyAnnals of Internal Medicine, 2001
- Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cellsBritish Journal of Cancer, 2001
- Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinasesNature, 1999
- The prevalence of complementary/Alternative medicine in cancerCancer, 1998
- Complementary medicine: a review of immunomodulatory effects of Chinese herbal medicinesThe American Journal of Clinical Nutrition, 1997
- Old Chinese Herbal Medicine Used for Fever Yields Possible New Alzheimer Disease TherapyJAMA, 1997
- Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell LinesJNCI Journal of the National Cancer Institute, 1991
- Automatic generation of 3D-atomic coordinates for organic moleculesTetrahedron Computer Methodology, 1990